Molecular and Cellular Biology

NADPH Oxidases

Principal Investigators :

 

Françoise Miot, PhD

fm2011

Françoise Miot obtained a Master's degree in Biochemical Sciences from the Université Libre de Bruxelles (ULB-1979). After her PhD in Biochemical Sciences "Study of the mechanisms controlling cAMP accumulation by phosphodiesterase activity" (IRIBHM-ULB-1986), Françoise performed a postdoctoral training at the Catholic University of Leuven (KUL) in the laboratory of Pr. De Wulf (1986-1988). Until 1991, she worked in the Unit of Biomedical Magnetic Resonance (ULB-VUB).
She obtained a permanent research position in the IRIBHM research center in 1991, and founded the DUOX laboratory with Dr. B. Corvilain in 1997.

 

 

 

Bernard Corvilain, MD

BC

Bernard Corvilain graduated as a Medical Doctor in 1984 and was board certified in Internal Medicine in 1992 at ULB. Bernard obtained his PhD in Medical sciences "Regulation of the thyroid H2O2 generating system: Implications in the control of the thyroid hormone biosynthesis" (IRIBHM-ULB-1995). He received a research fellowship from the Erasme Foundation (1987-1988, 1998-1999) and he was a research assistant from the Belgian National Research Scientific Fund (FRS-FNRS - 1988-1990).
Bernard is now the clinical director of the endocrinology department at the Erasme Hospital (ULB) and board member of the Belgian Thyroid Club.

  

 

 

Xavier De Deken, PhD

XDD3

Xavier De Deken obtained a Master's degree in Biomedical Sciences from ULB (1997). After his PhD in Biomedical Sciences "cloning and the characterization of the thyroid H2O2 generating system (2002 - ULB), Xavier performed a postdoctoral training at the IRCM, Montreal, Canada (2002-2004). Xavier joined back the laboratory in 2004 as a postdoctoral fellow.
He obtained a permanent research position in the lab in 2010. His main research interests concern the biochemical characterization of the DUOX oxidases and their role in pathophysiological processes.
 
 

 

 

 

PhD Students :

 

Zineb Eskalli

Zineb_E

 
Zineb Eskalli obtained her Master’s degree in Biomedical Sciences from ULB (2011). She started her PhD in Biomedical Sciences in 2011 at IRIBHM-ULB. Her main research concerns are the study of the roles exerted by the H2O2 generated by the DUOX enzymes in various pathologies like autoimmune thyroid diseases and cancer in human and transgenic mice models.

 

 

 

 

Nicoletta Giusti

NG
Nicoletta Giusti obtained a Master's degree in Medical Biotechnology in 2010 from the University of Perugia (Italy) and a Master's degree in Bioinformatic in 2012 from the University "La Sapienza" of Roma (Italy). She joined the DUOX Lab in January 2013 starting her PhD in  Biomedical Sciences at ULB. Her main research concerns are the characterization of the thyroid-H2O2 generating system during the zebrafish development and investigate in vivo the pathological implications of a sustained production of H2O2 in the thyroid. 
 
 

 

   

Louise Poncelet

LP
Louise Poncelet obtained her Master’s degree in Biomedical Sciences from ULB (2013). She started her PhD in Biomedical Sciences in 2013 at IRIBHM-ULB. Her main research concerns are the study of the molecular mechanisms involved in the regulation of DUOX activity and maturation mediated by their maturation factors DUOXA and the in vivo investigation of the pathological consequences of a sustained H2O2 generation in novel transgenic mouse models.
 
 
 

 

 

 

Postdoctoral Fellows :

 

 

Technicians :

 

Chantal Degraef

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Bernadette Bournonville

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Alumni :

 

Dantong Wang, PhD

Dantong Wang started his PhD in Biomedical Sciences in 2001 in the DUOX Lab. His main research project was to screen for novel DUOX partners and to characterize the expression and maturation of the components of the thyroid-H2O2 generating system. He obtained his PhD in 2005 and started a postdoctoral training at the McGill University in Montreal Canada studying C. elegans growing and senescence.

 

Janus Pachucki, PhD

Janus Pachuki joined the DUOX Lab in 2001 as a postdoctoral fellow. His main's research project was the structural and functional characterization of the two human DUOX genes and their 5'-flanking regions. He left the Lab in 2003 to go back in Poland.
 

Milutin Milenkovic, PhD

Milutin Milenkovic started his PhD in Biomedical Sciences in 2003 in the DUOX Lab. His main's research project was the study of TSH-mediated DUOX expression in mice treated with thyroid hormones or anti-thyroid drugs and the expression of DUOX during mouse development. He left the Lab in 2009.

 

Sabrina Rigutto, PhD

Sabrina Rigutto obtained a Master's degree in Biomedical Sciences from ULB (2004). She started her PhD in Biomedical Sciences in 2004 in the DUOX Lab. Her main research project was the study of the regulation of DUOX catalytic activities by post-translational modifications (calcium and phosphorylations) in transfected cells. She obtained her PhD in 2010.

 

Candice Hoste, PhD

Candice Hoste obtained a Master's degree in Biomedical Sciences from ULB (2006). She started her PhD in Biomedical Sciences in 2006 at IRIBHM-ULB. Her main research concerns are the study of the roles exerted by DUOX enzymes in various tissues and the characterization of DUOX/DUOXA partnership. She obtained her PhD in 2011. She left the lab in 2012.

 

Houssam Raad, PhD

Houssam Raad obtained a Master’s degree in Biochemistry and a PhD degree in Cellular and Molecular Biology from the University of Paris XI (2008), studying NOX2 and p67phox phosphorylation in human neutrophils and their role in NADPH oxidase activation. He joined the laboratory in 2009 as a postdoctoral fellow and studies DUOX / DUOXA expression in thyrocytes and their roles in pathophysiological processes. Houssam Raad left the lab for France in 2011.

 

 Ielham Hadad

Ielham Hadad obtained a Master's degree in Biomedical Sciences from ULB (2005). Ielham performed a DEA in Sciences "Study of the cardiac remodeling after cellular therapy in a model of chronic infarction" (ULB-2006).
She started her PhD in Biomedical Sciences in 2007 at ULB "Role of SDF-1/CXCR4 in interactions between mesenchymal and cardiomyocytes : A way to improve myocardial stem cells therapy", and joined the lab in 2008 to learn novel molecular and cellular biology techniques required to complete her thesis. She is now a scientific assistant in Biology (BA1) and in Physiology (BA2) of the Medical School (ULB).

 

Chiraz Ghaddhab

Chiraz Ghaddhab received her Medical Degree from the Université Libre de Bruxelles in 2006. From 2006 to 2010, Chiraz has been resident in the pediatric department of the "Hôpital Universitaire des Enfants Reine Fabiola". She joined the lab in october 2010 for a PhD training in Medical Sciences. She is studying the role of hydrogen peroxide in cancer development.
 
Catholic university of Leuven (KUL)

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