MOLECULAR AND CELLULAR BIOLOGY LABORATORY
From H2O2 generator DUOX to oxidative stress and cancer development.
Welcome to the DUOX Lab Web site!
Our research group is part of the Institute of Interdisciplinary Research, IRIBHM (Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire). This research center is localized at the Medical School of the University of Brussels (Université Libre de Bruxelles, ULB).
Hydrogen peroxide (H2O2) is a highly reactive chemical molecule originally considered as an antibacterial agent. In excess, H2O2 induces an oxidative stress responsible for different pathologies like cardiovascular disease, neurodegeneration, tumorigenesis or ageing. It is now widely accepted that many cell types other than the phagocytes produce reactive oxygen species (ROS).
The thyroid tissue generates massive amounts of H2O2 that are required for the biosynthesis of thyroid hormones T3/T4. In 2000, we discovered and characterized the molecular nature of the molecules responsible for this H2O2 generating system: the DUOX1 and DUOX2 enzymes. These proteins belong to a new family of proteins, the NADPH-oxidases, presenting a catalytic domain involved in ROS generation. The DUOX are also present at the mucosal surface of the digestive and respiratory epithelia.